Nexgard Spectra has the following features: There is a reason why Nexgard spectra has received such positive reviews its effectiveness, powerful blend of ingredients and easy administration makes it a top preventive product for pets. treat all important intestinal worms. months to protect against Paralysis Ticks and Fleas. With an ever-growing number of flea and tick prevention products for pets released each year, eggs in The https:// ensures that you are connecting to the Through its efficacy against fleas, NexGard Spectra treatment provided indirect prevention of D. caninum infestation. Merial 29 avenue Tony Garnier 69007 On Day 2, the mean body weight of dogs was 16.76kg (ranging from 12.74kg up to 22.00kg) for the negative control group, and 16.22kg (ranging from 12.40kg up to 19.26kg) for the NexGardSpectra treated group (p=0.6462), indicating homogeneity at the time of inclusion. Based on the prepatent period of approximately 21 days, and the last flea infestation on Day 28, it was considered that taking a margin of 21 more days, after Day 70, there was no biological possibility that a negative dog would become positive. the environment. read the label on medications carefully to ensure that your pet will be fully covered Ehrlichiosis. HHS Vulnerability Disclosure, Help Dogs appear to ingest fewer fleas than cats, which could explain why all cats were found infected by Dipylidium in a previous study [2], whereas only seven out of eight dogs were infected during a 2-month period of flea infesting challenges using 250 fleas per challenge. the most effective, and most importantly - which is the safest? which Remember that these are just examples. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea, Insecticide/acaricide resistance in fleas and ticks infesting dogs and cats, VICH Topic GL9 (GCP). larvae Some parasites may not pose a risk to your pet, depending on your area or lifestyle. Lebon W, Tielemans E, Rehbein S, Dumont P, Yoon S, Beugnet F, Jeannin P, Larsen D, Halos L. 2016. Nexgard path The tablet can be administered in two simple ways . The 100 fleas deposited weekly on each dog were not removed until Day 35, allowing enough time for their ingestion. 1 So have you purchased Nexgard Spectra for your dog yet? fleas, The infestation of cats and dogs, but also many other mammals including humans, is very common. The regular use of an effective anti-flea insecticide is important to protect pets against the various pathogenic effects related to flea infestation [10, 15]. The efficacy of treatment with NexGard Spectra was assessed in 10 dogs following weekly flea infestation with metacestode naturally infected fleas and compared with that in 10 untreated control dogs. sure you're selecting the right product for your dog! Due to the complete coverage offered by this combination, it is excellent value. administering different combinations of treatments. The tapeworm life cycle starts with the flea larvae ingesting the proglottids or egg packets containing the eggs of D. caninum in the environment; the eggs then hatch and the hexacanth embryos infect the flea larva. Prophylactic treatment of flea-infested cats with an imidacloprid/flumethrin collar to forestall infection with. Moreover, this advanced formula is effective against various types of mange, including demodectic mange, sarcoptic mange, and otodectic mange. Prefer using external treatments? See our product comparison below for an easy guide to flea, tick and worming treatments and ClinVet International (Pty) Ltd 9321 and transmitted securely. They were acclimatised to the study site for 7days before the start, and they were clinically healthy as determined by a veterinarian on Day 7. Assignment of codes (codes A and B) to the study groups and administration of the treatment was the responsibility of non-blinded personnel. Under natural field conditions, the infection rate of fleas seems to be quite low, from 2% to 5% of Dipylidium-infected fleas, based on recent flea surveys in Europe [5]. The floor size of each dog cage was 2.0m3.0m. On Day 35, after the final flea count and removal, all dogs were moved to an outside unit. tapeworm, and a separate treatment may be required. all common parasites. Now just one tasty chew will address both lungworm and ticks, meaning that pet owners dont have to concern themselves with administering different products and vets know that in the face of a rapidly changing situation there is a simple way to make sure their patients are protected.. Based on previous studies, this was demonstrated to be sensitive enough to recover all infected animals [2, 3]. Products such as Neovela, Sentinel, Advocate, or Revolution fit in this

Myths and realities. Prevents heartworm disease very effectively. actually The protocols were submitted to the ClinVet Animal Ethics Committee (CAEC).

Efficacy of oral afoxolaner plus milbemycin oxime chewables against induced gastrointestinal nematode infections in dogs. this changes year by year. Guideline on Good Clinical Practices, The European Agency for the Evaluation of Medicinal Products (EMWA/CVMP/VICH/595/98-Final). A As previously published [2, 13], the experimental flea-infection model worked well, producing a population of Dipylidium metacestode-infected fleas, at a rate of 1033%. 8600 Rockville Pike Allergies in Dogs. NexGard Spectra can be used from 8 weeks of age in puppies weighing more than 2 kgs, and is very well tolerated, including by MDR-1 mutant collies, where studies showed no treatment-related changes even at five times the maximum dose. The level of significance of the formal tests was set at 5%, all tests were two-sided. Which products treat which parasites? Dipylidium infection can also be assessed by polymerase chain reaction (PCR); it is of interest for epidemiological surveys based on flea analyses [5]. 3. There is currently no single-dose product that covers absolutely every significant Still confused? Letendre L, Harriman J, Drag M, Mullins A, Malinski T, Rhebein S. 2016. NexGard Spectra is a trademark of Merial Animal Health Ltd. Merial Ltd 2017. All the dogs were observed daily by technicians from Day 7 to Day 70 for their general health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, GUID:4FC900BC-F943-4087-BECC-2DBB79D1B59B. The experimental unit was designed in compliance with the South African National Standard SANS 10386:2008 The care and use of animals for scientific purposes. In some areas your pets will need protection from other irritating insects. Fourie JJ, Crafford D, Horak IG, Stanneck D. 2012. Bravecto

2013. The dogs included in the study were mixed breed dogs, originating from the facility, 6months of age. Intestinal worms - Worms that live in the gastrointestinal tract including whipworm, tablet is available from your vet, which usually costs between $3-6. In the present study, 7 out of 10 control dogs were infected after the 4 flea challenges using 100 fleas each. Animals infested with fleas groom themselves and ingest fleas. We assumed that by killing fleas within 1224h during the whole month [3, 9], even if killed fleas were ingested, afoxolaner provided an indirect protective effect against D. caninum infection.

In a recent publication based on the collection of fleas on 435 cats and 178 dogs in Europe, 5.2% of 732 C. felis and 2.2% of 1969 C. felis were found to be infected by D. caninum, which indicates that this tapeworm is probably more common than veterinarians may think [5]. A sample of 30 fleas was examined before each weekly flea challenge. There are 3 species in Australia: The Only the Paralysis Tick is intestinal worms - and ticks. Previously, Australia was Credelio provides coverage against fleas and ticks while Interceptor protects your dog against heartworm and intestinal worms including tapeworm. Based on available data, it seems that metacestodes need 2436h to become infective for the definitive host, which is temperature-related [20, 21]. Les 100 puces dposes chaque semaine sur chaque chien nont pas t enleves jusquau jour 35, ce qui donnait suffisamment de temps pour leur ingestion. Which flea prevention is This development is temperature dependent (with an optimal temperature of 32C) and is related to the presence of the fleas on the host skin. Lefficacit du traitement de 10 chiens avec NexGard Spectra a t value suite une infestation hebdomadaire avec des puces infectes naturellement par des mtacestodes et compare 10 chiens tmoins non traits.

contains a few eggs!). for Does newer mean better? The NexGard Spectra treatment was administered once on Day 0 at the doses indicated in Table 2.

Flea infestations often induce clinical signs in dogs such as pruritus, hair loss and flea allergy dermatitis [14, 19], and increase the risk of pathogen transmission including Bartonella spp. Fleas were not combed, counted nor removed until Day 35. The assessment criterion was the presence or absence of D. caninum infection by daily macroscopical examination of both faeces and cage floors from Day 28 to Day 70. This product is known as the next-gen product for dogs due to its exceptional qualities. A statistically significant difference was observed between the negative control group and the treatment group(p<0.0031). Alternatives to Credelio include Nexgard or Simparica. As the faeces of the dog were normal afterwards and the dog showed no other clinical signs (fever, pain, etc.

There are, however a few products which come close. Angiostrongylus vasorum is spreading across the UK, with prevalence in foxes rising from 7% in 2005 to 18% in 20141,2. NexGard Spectra and Frontline Combo are registered trademarks of Merial. The signs were mild and resolved spontaneously without therapy. The intravenous and oral pharmacokinetics of afoxolaner and milbemycin oxime when used as a combination chewable parasiticide for dogs, Journal of Veterinary Pharmacology and Therapeutics. Rehbein S, Knaus M, Mallouk Y, Breiltgens T, Brianti E, Capri B, Dantas-Torres F, Gau M, Joachim A, Kaulfu K, Kirkova Z, Lechner J, Mihalca A, Mirabito R, Petkeviius S, Rapti D, Shukullari E, Sedeilhan M, Dollhofer D, Kley K, Lebon W, Visser M, Jeannin P. 2017. A veterinarian conducted a clinical examination on all dogs during acclimatisation for enrollment on Day 7 and then again on Days 2, 35 and 70. However, dogs still had visual and auditory contact with conspecifics. With so many preventatives lacking This article is written by Pet Circle Veterinarian, Dr Carla We've put together a helpful guide to parasites and prevention products, so that you can be Only feed Nexgard Spectra to dogs that are over 8 weeks old. Also NexGard Spectra also kills fleas and treats gastro-intestinal (GI) roundworms, such as Toxocara, making it a suitable treatment for family pets where zoonotic risks need to be considered. National Library of Medicine Swainsbury et al (2016) Vet Rec 178, 172. Here are some safety measures to keep in mind when you are using Nexgard Spectra for your dog. heart. All dogs were experimentally infested with 100 C. felis fleas that were infected with a dog strain of D. caninum, on Days 7, 14, 21 and 28. This document is provided for scientific purposes only.

The purpose was to administer a dose as close as possible to the minimum dose of afoxolaner (2.5mg/kg) and milbemycin oxime (0.5mg/kg), so that all dogs received a similar concentration of the active ingredients in mg/kg. hydatid tapeworm coverage (such as Nexgard Spectra, Neovela, and Advocate), many pet owners Why not Ask a Pet Circle Vet for some guidance. To assess the prophylactic effect of anti-flea treatment, it was first necessary to produce Dipylidium-infected fleas. Beugnet F, Labuschagne M, Fourie J, Guillot J, Farkas R, Cozma V, Halos L, Hellmann K, Knaus M, Rehbein S. 2014. Another dog in the treatment group showed signs of hair loss on the left and right flanks during the study on Day 43. tapeworm-only Do not overdose your pet with more than one chewable a month. It is waterproof and fragrance-free. Break the chewable into pieces and mix the same with the dogs food.

Australian parasite. wonder if tapeworm is really that important. Federal government websites often end in .gov or .mil. category Always It is intended to protect dogs against flea and tick infestation, and to deworm against gastro-intestinal nematodes as well as some other nematode infections (Dirofilaria immitis, Angiostrongylus vasorum) [9, 12, 16, 22].

For more information, veterinary professionals should contact their Merial Territory Manager, call Merial on 0870 6000 123, or visit www.nexgardspectra.co.uk. In order to provide protection against D. caninum infection, the anti-flea treatment needs to kill fleas before the maturation of the metacestodes [2, 20, 21]. ticks, intestinal worms, and heartworm. Ehrlichiosis to ensure your dog is protected. Fleas and ticks are everywhere, and these creepy critters can harm your dog during any season. NexGard Spectra for dogs contains afoxolaner and milbemycin oxime. If you are unsure as to which treatment The dog cages were environmentally controlled for temperature (20C4C). The Learn more about common parasites with our article A Guide To Fleas, Ticks, Worms and In the present study, we assessed the protection against D. caninum infection conferred by the oral administration of NexGard Spectra (Merial) to dogs. Any reference to a brand or trademark herein is for information purposes only and is not intended for any commercial purposes or to dilute the rights of the respective owners of the brand(s) or trademark(s). The new dog cages consisted of a 1.70m0.7m enclosed sleeping area and an outside run of 1.70m3.0m. A roof covered the kennels and the dogs were not exposed to rain. The product offers a unique combination of actives: afoxolaner, an isoxazoline with proven efficacy against ectoparasites, and milbemycin oxime, a tried and tested option for lungworm prevention and GI roundworms. 2. Administered tablet doses per individual dog in treated group. As soon as you suspect fleas and ticks on your fur buddy, it is essential to get rid of them without any delay.

generally considered free of this disease.

Dipylidium caninum is common worldwide, infecting both cats and dogs, and is zoonotic, even though human infection is very rare [7]. Learn more to embark on, it is always best to consult with a professional. venomous.

skin Advocate, Neovela, or Revolution - a monthly In order to do this, donor dogs infected with D. caninum, as confirmed by proglottid observation in faeces, were also infested with C. felis fleas. On Day 35, one dog from the treated group had erythema on the abdomen and inguinal area. mite Demodex and ear mite Otodectes, can pose a risk, particularly to Universitas South Africa. For the first time in May 2020, Ehrlichiosis was detected in dogs in Australia with areas in It is available in packs of three chews, with five different presentations to ensure accurate dosing according to bodyweight (2-3.5 kgs, 3.5-7.5 kgs, 7.5-15 kgs, 15-30 kgs and 30-60 kgs). We're

Flea batches and infection rates used per infection. - Paralysis ticks tend to only live along the The hair loss was considered not related to the treatment. and may be perfect for dogs in areas like Perth or Adelaide. For further information about side effects, precautions, warnings and contraindications refer to the product packaging or contact Merial Animal Health Ltd, CM19 5TG, UK. recommend tapeworm prevention for every dog. Paszkowski. The mixture was then transferred to a classic flea breeding unit, containing a mixture of sand and crushed dried cat food, to ensure that the flea larvae could feed and develop adequately to pupae and newly emerged fleas within 2weeks. Fleas recovered from the control and treated dogs on Day 35.

The cat flea is also the intermediate host of a tapeworm, Dipylidium caninum (Linnaeus, 1758) [7, 8]. The truth is, different species of tapeworm can be transmitted from fleas, As you can see, Nexgard Spectra is a top product, and due to its excellent qualities, it is certainly the next-gen product for dogs. it's not surprising that Australian pet owners are often left feeling a little confused. Safe use of Nexgard Spectra has not been evaluated in pregnant, lactating, and breeding dogs. Feeding Guidelines of Nexgard Spectra for Dogs, Since Nexgard Spectra is a chewable, it is extremely easy to feed your dog. Thats about to change as NexGard Spectra is now licensed for lungworm prevention, making it the only product that prevents lungworm and kills ticks in one tasty chew. Nexgard Spectra kills all significant parasites apart from the hydatid about navigating our updated article layout. You may combine this with a tapeworm-only tablet from your vet, which usually cost Safe for all dog breeds and puppies over the age of 8 weeks. The dog received concomitant topical essential oil therapy (Dermoscent, LDCA) and the skin condition started to improve. Within blocks, dogs were randomly allocated to the two groups. covers for 'everything except ticks', (ie, fleas, worms, and heartworm). In this study, the efficacy criterion was based on the collection of Dipylidium proglottids, either on dogs faeces or on cage floors. These dogs had not been treated with a long-acting topical or systemic acaricide/insecticide during the 12 weeks preceding Day 0, and the females were not pregnant. (You never know if that dog poo at the park Three flea batches were used during the study. Being able to use one product thats easy to give will make protecting pets against the two most concerning pet parasites much simpler. The flea eggs started hatching after approximately 23 days, and the flea larvae were maintained with the sieved material for another 2 days (i.e., up to about 6 days after sieving). Want to receive regular updates of our latest news, promotions, offers and products launches? Seven out of the 10 dogs in the negative control group were found to be positively infected with D.caninum: one dog on Day 35, one on Day 37, one on Day 38, one on Day43, one on Day 51, one on Day 63 and one on Day 65. While numerous products can help you to get rid of these pesky parasites, there is none better than Nexgard Spectra. Dipylidium metacestode development occurred in parallel to flea development. The first and last authors are employees of Merial, which produces the veterinary drugs used in these studies. puppies. In addition to providing monthly flea and tick control and a deworming effect against roundworms, hookworms, whipworms, heartworm larvae and lungworm [12, 16, 17, 22], the regular monthly use of NexGard Spectra should indirectly help to prevent the infection of dogs by D. caninum. coastline of Australia, however some odd cases may occur as far west as Melbourne. For further information read our article Everything You Need To Know About Following the original description by Venard [24], Pugh identified seven morphological stages of the Dipylidium metacestode during its maturation and preferred to avoid using the term cysticercoid larvae [20, 21]. Bethesda, MD 20894, Web Policies For example, some medications that appear to treat intestinal worms do not necessarily treat

Beugnet F, deVos C, Liebenberg J, Halos L, Fourie J. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs, Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. available as alas, Percentage efficacy at the end of the study was calculated using the following formula: SAS Version 9.3 TS Level 1M2 was used for all the statistical analyses. Smith et al (2011) Med & Vet Entom 25, 377-384. to between $3-6. a spot-on treatment, if you prefer topicals.Bravecto Paralysis Tick, The Brown Dog Tick, and the Bush Tick. Heartworm - blood-dwelling worms transmitted by mosquitos. The only major parasite that none of them cover is the hydatid tapeworm - however this parasite is generally only considered a risk if your pet has access to dead animal carcasses or raw offal. in The hexacanth embryos develop in immature flea stages in 9 to 19 days to non-infective metacestodes that stay quiescent in the flea pupae [6, 20, 21]. Nexgard Spectra is made up of two key ingredients known as Afoxolaner and Milbemycin Oxime. Nexgard Spectra is a beef-flavoured chewable that effectively kills fleas and ticks. Marchiondo AA, Holdsworth PA, Fourie LJ, Rugg D, Hellmann K, Snyder DE, Dryden MW. The efficacy of a monthly oral endectocide product, NexGard Spectra (Merial), a combination of afoxolaner and milbemycin oxime, was evaluated in a flea (Ctenocephalides felis) challenge model for the prevention of Dipylidium caninum tapeworm infection in dogs. government site.

Reduces flea egg production and flea population. Each of the 30 fleas was dissected and then examined microscopically to determine the presence or absence of D. caninum metacestodes (Table 3). Before we dive into the specifications of Nexgard Spectra, it is only fair to first tell you what Nexgard Spectra is all about. Abdullah et al (2016) Parasites & Vectors 9: 391 4. Keep product far away from the reach of children. Spot World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) But as both parasites have changed their behavior, the risk of exposure has increased across the country. To help you decide which product might work for you, we've outlined a few combination options The risk of exposure to ticks has increased, with a recent study showing that nearly 1 in 3 dogs were found to host ticks3, compared to around 1 in 7 dogs in a previous study4 Cases of the potentially fatal tick-borne disease Babesiosis (carried by the tick vector Dermacentor reticulatus) are also being diagnosed in un-travelled UK dogs5. Want to read more? Heartworm. Bravecto and Drontal are a great combination for 3-monthly coverage.

spot on that treats fleas, heartworm and intestinal worms except for tapeworm. After administering, make sure you wash your hands thoroughly with soap and water. These guys cause intense itching and dermatitis. NexGard Spectra is an oral chewable formulation containing afoxolaner, an insecticidal-acaricidal compound of the isoxazoline family, and milbemycin oxime, a nematodicidal compound [17]. None of the dogs were removed from the study prior to study termination. The absence and presence of proglottids were compared between the groups using a 2 test or a Fishers exact test when one or more of the cells had a frequency of five or less. To date, in order to help protect pets against both of these parasites vets have had to prescribe multiple products, often with different methods of administration and/or treatment frequencies, leading to potential client confusion and issues with compliance. As already demonstrated for two topical products (Frontline Combo and Certifect, Merial) and one collar (Seresto, Bayer), the oral administration of NexGard Spectra to dogs was 100% effective in preventing infections with D. caninum, despite the fact that 100 fleas were applied to each dog four times, at weekly interval (Days, 7, 14, 21 and 28). NexGard Spectra for dogs is indicated for the treatment of flea and tick infestations in dogs when the concurrent prevention of heartworm disease, angiostrongylosis (reduction in level of immature adults (L5) and adults of Angiostrongylus vasorum) and/or treatment of gastrointestinal nematodes infestations is indicated. The cat flea, Ctenocephalides felis felis Bouch, 1835, is widespread all over the world [10, 14, 15, 23]. will also be available for a limited time. Want to know more? In order to demonstrate that this efficacy would be obtained whatever the weight of the treated dogs, the minimum effective dose was used (i.e. Microscopical coproscopy is known to have poor sensitivity and would bring no any additional benefit to the experimental design used here. All other marks are the property of their respective owners. Efficacy against nematode infections and safety of afoxolaner plus milbemycin oxime chewable tablets in domestic dogs under field conditions in Europe, The biology, ecology, and management of the cat flea, Morphology, bionomics and taxonomy of the cestode, Annals of the New York Academy of Sciences, http://creativecommons.org/licenses/by/4.0, http://www.parasite.org/10.1051/parasite/2017017/olm, http://www.ema.europa.eu/docs/enGB/documentlibrary/Scientificguideline/2009/10/WC500004343.pdf, Chewable tablets for dogs > 3.5kg7.5kg, Chewable tablets for dogs > 7.5kg15.0kg, Chewable tablets for dogs > 15.0kg30.0kg, Chewable tablets for dogs > 30.0kg60.0kg, 7/10 Days of diagnosis: 35, 37, 38, 43, 51, 63 and 65.