Standard Process products labeled as Vegan are devoid of animal-based tissue, animal-based gelatin, or fish oils. doi: 10.1111/j.1745-7254.2007.00651.x, 51.

These herbs provide many phytochemicals including an essential oil (containing monoterpenes and other terpenes), the naphthodianthrones hypericin and pseudohypericin (hypericins), flavonoids, phenolics, triterpenoid saponins (especially glycyrrhizin) and other saponins. Clin Nutr Edinb Scotl. By boosting Vitamin C uptake through food or Ascorbic acid supplements, Vitamin C is found to decrease oxidative damage, promoting health and lowering the risk of certain conditions. (2012) 3:3003.

This results in hyper inflammation of tissues and subsequent tissue fibrosis and pneumonia (4, 7, 10). doi: 10.1016/j.ejphar.2006.03.002, 65.

(2020).

The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections.

These findings indicate the strong anti-inflammatory activity of the piperine. SARSCoV-2 cell entry depends on ace2 and tmprss2 and is blocked by a clinically proven protease inhibitor. Standard Process products labeled as Non-Soy or Non-Soy Formula have been formulated to not contain soy or soy-derived ingredients.

doi: 10.1055/s-2006-961504, 70. Potential effects of curcumin in the treatment of COVID-19 infection.

Figure 1.

In general, probiotics exert anti-inflammatory and immunomodulatory effects via modulation of the NF-B, MAPK and pattern recognition receptors (PRR) pathways that decreases Th2 mediated responses and upregulates Th1 responses.

The immunomodulatory role of probiotics in allergy therapy. doi: 10.3892/ijmm.19.3.469, 52. doi: 10.1056/NEJMoa2001316, 4.

Recent studies have suggested EGCG may possess antiviral capacities against a broad range of RNA and DNA viruses.

(2020). intended to diagnose, treat, cure, or prevent disease. I strongly endorse the old fashion remedy of hot baths.

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: a recent update.

Roth DE, Richard SA, Black RE. Quercetin and vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARSCoV-2 related disease (COVID-19). World J Gastroenterol.

Biosci Biotechnol Biochem. Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-/ at the Initial Stage of Influenza A Virus (H3N2) Infection.

Also, it found to inhibit the production of IL-2, and IFN- in human peripheral blood mononuclear cells (PBMCs) (74). (2019) 2:2837. Here we find what to fix, and fix what we find. SARS-CoV-2 infection involves two phases: (1) Asymptomatic carrier phase.

Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection.

Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS).

doi: 10.20944/preprints202003.0226.v1, 57.

(2010) 68:67181.

Liao, L. Y., He, Y. F., Li, L., Meng, H., Dong, Y. M., Yi, F., & Xiao, P. G. (2018).

The rhinovirus is a single-stranded RNA virus that is responsible for most upper respiratory tract infections. This vitamin supports the function of various immune cells and enhances their ability to protect against infection.

Role of Selenium in HIV infection.

TUESDAY: 8:30 am-5:00 pm

It downregulates PGEs by inhibiting the expression levels of IL-6 and matrix metalloproteinases (MMP-13) (71). Siegers CP, Rbke A, Pentz R. Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes.

SUNDAY: CLOSED, Wholistic Health Services of Vermont | Sitemap | Accessibility | Website by DOCTOR Multimedia. The elevated cytokines also trigger induction of endothelium HA-synthase-2 (HAS2) in alveolar epithelial cells (type 2), and fibroblasts (15).

(2017) 27. doi: 10.1002/rmv.1909, 36.

Lancet Respir Med.

Lf inhibits viral entry via binding to cell surface molecules or viral particles or both. doi: 10.1271/bbb.90749, 94.

sunlight, tanning) when using this product. VD a fat-soluble vitamin, plays a vital role in both in immunomodulatory, antioxidant and antiviral responses (29, 30). In a randomized controlled trial (RCT), VD supplementation of monthly high-dose (100,000 IU/month) in comparison to a standard dose (12,000 IU/month) helps in reducing the incidence of acute respiratory infections especially in older long-term care residents (37).

Millar AB, Pavia D, Agnew JE, Lopez-Vidriero MT, Lauque D, Clarke SW. Effect of oral N-acetylcysteine on mucus clearance. Furthermore, evidence also suggests that VD can supplement the effectiveness of drug treatment as observed in the case of ribavirin therapy for treatment-nave patients with chronic Hepatitis C virus (HCV) genotype 1 and HCV genotype 2e3 infections (33, 34, 38, 39).

On the other hand, selenium supplementation demonstrates the improved CD+ T cell counts (80) and improves glutathione peroxidase and other antioxidant selenoenzymes along with catalase activities (81).

Wu, W., Li, R., Li, X., He, J., Jiang, S., Liu, S., & Yang, J.

Biol Pharm Bull.

Also, suppresses severe inflammation in tissues such as lungs and intestine (77). From the point of prevention, phase 1 is crucial as individuals in this stage are carriers, they can spread the infection unknowingly. J Appl Toxicol. Chem Biol Interact.

The virus has the positive-sense RNA as its genome encoding for ~26 proteins that work together for the virus survival, replication, and spread in the host.

Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.

Wu YH, Tseng CP, Cheng ML, Ho HY, Shih SR, Chiu DTY. Excellent foods such as garlic, lemons, green tea, cayenne and chicken soup.

The immunomodulatory activity is attributed to flavonoids and some phenolic acids mainly caffeic acid phenethyl esters and artepillin C (3,5-diprenyl-4-hydroxycinnamic acid). Hajavi J, Esmaeili SA, Varasteh AR, Vazini H, Atabati H, Mardani F, et al.

Agarwal R, Goel SK, Behari JR. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. (2013) 2013:751068. doi: 10.1155/2013/751068, 90. doi: 10.1016/S0140-6736(20)30154-9, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Am Rev Respir Dis. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.

I do have other vegetarian immune boosters as well. (2014) 28:1067.4. doi: 10.1096/fasebj.28.1_supplement.1067.4, 25. te Velthuis AJW, van den Worm SHE, Sims AC, Baric RS, Snijder EJ, van Hemert MJ.

These herbs have been traditionally used in herbal preparations to: This combination of herbs provides many phytochemicals including an essential oil (containing monoterpenes and other terpenes), the naphthodianthrones hypericin and pseudohypericin (hypericins), flavonoids, phenolics, triterpenoid saponins (especially glycyrrhizin) and other saponins. Hudson, J., & Vimalanathan, S. (2011). The commonly used probiotics are Bifidobacterium and Lactobacillus species, followed by the Streptococcus, Enterococcus, Bacillus, and Escherichia coli. (2014) 2014:642942. doi: 10.1155/2014/642942, 62.

Mahmoodpoor A, Hamishehkar H, Shadvar K, Ostadi Z, Sanaie S, Saghaleini SH, et al. Vitamin D receptor inhibits nuclear factor B activation by interacting with IB kinase protein.

(2020) 8:186. doi: 10.3389/fpubh.2020.00186, 89.

Further, quercetin metabolite (4',5-diacetyloxy-3,3',7-trimethoxyflavone) has been shown to inhibit the picornavirus replication by inhibiting the RNA replicase complex (107).

Potential interventions for novel coronavirus in China: a systematic review.

common cold). Dirsch VM, Gerbes AL, Vollmar AM.

Matrix Biol J Int Soc Matrix Biol.

A clinical study has reported that administration of Leuconostoc mesenteroides 32-77:1, Lactobacillus plantarum 2,362, L. paracasei ssp.

Some of these include: 1 Kim, Y., Kim, H., Bae, S., Choi, J., Lim, S. Y., Lee, N., Kong, J. M., Hwang, Y. I., Kang, J. S., & Lee, W. J. Impact of vitamin D supplementation on influenza vaccine response and immune functions in deficient elderly persons: a randomized placebo-controlled trial. doi: 10.1016/j.fct.2015.05.022, 53. Exp Lung Res. 1985;79(3):262266. Rev Med Virol.

The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. doi: 10.1007/s00268-005-0653-1, 93.

Standard Process products labeled as Vegetarian are considered lacto-ovo vegetarian, which means they are devoid of animal-based tissue, animal-based gelatin, or fish oil.

Zinc can also modulate the viral entry, fusion, replication, viral protein translation and virus budding of respiratory viruses (19, 23).

Chong HX, Yusoff NAA, Hor YY, Lew LC, Jaafar MH, Choi SB, et al. This study was supported by the Department of Biotechnology (DBT)-Ramalingaswami Fellowship (BT/HRD/35/02/2006), Department of Science and Technology-Science and Engineering Research Board (DST-SERB) (EMR/2016/007994), Govt.

The main compound responsible for the herbs therapeutic properties is a catechin called Epigallocatechin-3-O-gallate (EGCG). Furthermore, piperine treatment found to reduce the production of pro-inflammatory cytokines such as IL-1, IL-6, TNF-, COX-2, nitric oxide synthase-2, and NF-B in the cerebral ischemia-reperfusion-induced inflammation rat model (75).

The majority of autopsies have shown that infected lungs are filled with clear liquid jelly, which resembles the lungs of wet drowning (17). Other Ingredients: Microcrystalline cellulose, sodium starch glycolate, dextrin, croscarmellose sodium, silicon dioxide, maltodextrin, magnesium stearate, hypromellose and dibasic calcium phosphate dihydrate.

This process utilizes: Standardized ingredients and quantified activity levels are tested as necessary and allow MediHerb to ensure their formulas: MediHerb is a global leader in herbal scientific knowledge, often collaborating on research projects with reputable establishments worldwide.



Cinnamaldehyde is also known to downregulate the production of prostaglandins (PGEs) by downregulating IL-1-induced COX-2 activity thus lowering the chances of hyper inflammation in a dose-dependent manner (64).

Some of the garlic compounds that show viricidal activity are ajoene, allicin, allyl, methyl thiosulfinate and methyl allyl thiosulfinate (68, 69).

Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID-19.

(2020) 10:1028.

Phase 2: Symptomatic phase with high viral load (4). Standard Process sells through health care professionals.

Various spices, herbs, fruits, and vegetables have found to be excellent sources of VC (44).

Further, there no specific drug for use against COVID-19 as well as substantial data both at the national or international level on the effects of nutritional supplements on risk or severity of COVID-19.

Further, granulocytosis in response to SARS-CoV-2 infection also contributes to the production of super oxide ions, a type of ROS and for the additional production of pro-inflammatory cytokines (12). (2019) 8:30. doi: 10.3390/biology8020030, 31.

The chart can be found here: Potential Herb-Drug Interactions Chart. Nutrients. Chen Y, Zhang J, Ge X, Du J, Deb DK, Li YC. Zn deficiency shows up-regulation of TNF-, IFN-, and FasR signaling and induction of apoptosis in lung epithelial cells (21) and also up-regulates the Janus kinase (JAK)-STAT signaling in lungs under septic conditions (22). J Neurosci Res. (2015) 4:188. doi: 10.4103/1735-5362.192488, 100. Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: meta-analysis and meta-regression of randomized trials.

Binding interaction of quercetin-3--galactoside and its synthetic derivatives with SARSCoV 3CLpro: structureactivity relationship studies reveal salient pharmacophore features.

49.

Moreover, certain Quercetin-rich foods like red onion also act as a mucolytic agent, which help to expel stuck mucous and relieve congestion in the lungs.

Piperine that is obtained from ethanolic extract of black pepper and is a major alkaloid in the group of cinnamamides (71). Lang A, Lahav M, Sakhnini E, Barshack I, Fidder HH, Avidan B, et al.

Research has shown that supplementing with L-ascorbic acid can enhance the immune response to pathogens by up-regulating the activity of natural killer (NK) cells and of T lymphocytes immune cells that kill non-specific pathogens (NK) and specific antigens (T-cells) as well as produce immunological memory. Best avoided in epilepsy.

I would also consider Congaplex which is used for short-term support of the immune system. doi: 10.1080/09540105.2017.1343805, 80. J Clin Microbiol. Viruses,8(1), 6. https://doi.org/10.3390/v8010006, 7. Standard Process products labeled as Non-Dairy or Non-Dairy Formula have been formulated to not contain milk or milk-derived ingredients. Currently, several vaccines and drugs are being evaluated for their efficacy, safety, and for determination of doses for COVID-19 and this requires considerable time for their validation. Quercetin as an antiviral agent inhibits influenza A Virus (IAV) entry. So, if the immune system is weakened due to stress, age, diet, or genetics you had better do something to strengthen your army as it goes to war against invasive bugs. MM, VP, RN, and PJ: drafted the article. PubMed PMID: 15496046.

Similarly, there are several drug candidates that have been identified and most are in various stages of research and development, whilst some of them have been repurposed and approved for emergency use in this pandemic.

of India. Org Lett. doi: 10.1016/j.antiviral.2012.03.005.

doi: 10.4049/jimmunol.0803217, 34.

Thus they can derive the most significant benefit from the VD supplementation (41).

J Agric Food Chem.

Most importantly, key molecule hyaluronan (HA) has high water binding capacity up to 1,000 times its molecular weight. Hoffmann M, Kleine-Weber H, Schroeder S, Krger N, Herrler T, Erichsen S, et al.

92. For example, thyme fresh (267%RDA), turmeric (43%RDA), cardamom (35%RDA), coriander (35%RDA), beetroot juice are good sources of VC (45).

All the above evidences show cases that cinnamaldehyde is a potential anti-inflammatory bioactive compound and could be useful in mitigation of SARS-CoV-2 induced hyper inflammation in the lung.

(2013) 5:250221.

Studies explored the effects of elderberries on immunity and indicated that these berries improve immune function through their ability to increase cytokine activity signalling molecules that regulate immune responses and inflammation. Guo JY, Huo HR, Zhao BS, Liu HB, Li LF, Ma YY, et al. Once type 1 IFN is secreted, the virus interferes IFN signaling by inhibiting signal transducer and activator of transcription (STAT) 1 phosphorylation (9). (2007) 2:Doc18. Behera MK, Shukla SK, Dixit VK, Nath P, Abhilash VB, Asati PK, et al.

Probiotics not only support the health of the gut but also improves system functioning and regulation (86). [8], In addition, NAC has been found to improve respiratory health by helping to break down phlegm and decreasing inflammation in the lungs.

(2005) 28:171721.

FEMS Immunol Med Microbiol.

Please consult the product packaging label for the most accurate product information. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB.

Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS.

The mechanisms of how it modulates the host IFN response is not completely understood. Baicalin is a phytonutrient with a long history of use in traditional Chinese medicine for its potent anti-inflammatory compounds and positive effects on the immune and circulatory function. 1, 25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. Several shreds of evidence indicate that many nutritional supplements from various spices, herbs, fruits, roots, and vegetables can reduce the risk or severity of a wide range of viral infections by boosting the immune response, particularly among people with inadequate dietary sources and also by their anti-inflammatory, free radical scavenging, and viricidal functions.

doi: 10.1086/528377, 15. Many published articles have suggested that zinc may reduce the severity and duration of common colds due to zincs ionophoric activity that has antiviral effects against rhinoviruses (i.e.

doi: 10.1016/j.ejphar.2010.05.026, 73. doi: 10.3109/01902140903061787, 21.

I can give you more specifics on dosage if you email or call me. BioMed Research International, 2015, 111. Schreck Bird A, Gregory PJ, Jalloh MA, Risoldi Cochrane Z, Hein DJ. J Am Geriatr Soc. Wang-Sheng C, Jie A, Jian-Jun L, Lan H, Zeng-Bao X, Chang-Qing L. Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia. doi: 10.1093/jn/137.10.2190, 103. (2010) 74:93945. Viranon is an immune support formula containing Thuja, St Johns Wort and Licorice to support the bodys normal resistance function. This is linked to the compounds ability to block the primary stages of a viral infection, i.e.

Further, piperine is a potent antioxidant and protects against oxidative damage by neutralizing free radicals, ROS, and hydroxyl radicals.

Dworkin BM.

Though mechanism of their immunomodulating and anti-inflammatory effects in the lung are not clearly understood. (1999) 21:43543. Quercetin & Rutin (Quercetin-3-O-rutinoside) are a naturally occurring polyphenol and flavonoid, best known for its potent anti-inflammatory and immune-enhancing abilities.

Another great anti-viral plant is Green Tea (Camelia sinensis). Quercetin is a well-known antioxidant with anti-inflammatory and antiviral bioactive.

doi: 10.1016/j.jep.2010.10.032, 84.

(2000) 2:28413. Planta Med.

Vitamin C as mother nature intended. VC is also a potent antioxidant.

Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-B in middle cerebral artery occlusion rat model. Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. doi: 10.1016/j.jpha.2020.03.001, 10. Initial studies find that some of these have been found to possess anti-SARS-CoV-2 effects and are being fast-tracked into clinical trials (Table 2).

Open Forum Infect Dis.

(2009) 183:545867. Treating the person who has symptoms, Not treating the symptoms that has a person. (2006) 14:8295306. Their outstanding team of industry-leading professors, naturopaths, herbalists, scientists, and researchers ensure each product is of the highest quality. 2019;23(2):144.

(2017) 18:1985. doi: 10.3390/ijms18091985, 98. Studies have shown that oral supplementation of Zn reduces the occurrence of acute respiratory infections by 35%. DO NOT send personal health information through this form.

Studies have also shown that quercetin has antiviral effects on both RNA and DNA viruses. Food Chem Toxicol.

10. intended to diagnose, treat, cure, or prevent disease.

(2017) 28:137492.

Thus far, the infection has spread to almost all countries globally and was declared a pandemic by the WHO.

doi: 10.1186/ar2662, 72.

Methods Find Exp Clin Pharmacol. 2003 Feb;22(1):18-35. Review. Immunol Invest.

Consumption of Bifidobacterium and Lactobacillus have found to help in clearing the influenza virus in the respiratory tract (88).

WEDNESDAY: 1:00pm-3:00 pm

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al.

The details of the pathogenesis of SARS-CoV-2 infection is not clearly understood.

doi: 10.1128/JVI.78.20.11334-11339.2004, Keywords: SARS-CoV-2, COVID-19, pathogenesis, food supplements, immune-boosting, antioxidant, anti-inflammation, Citation: Mrityunjaya M, Pavithra V, Neelam R, Janhavi P, Halami PM and Ravindra PV (2020) Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19.